Canine Color Genetics. The American Bully is a relatively new breed. The two alleles associated with Genetics" itemprop="url">Read Here The genes from these breeds created a genetic pool in a massive amount, were humans took the best specimens for their needs, and continued breeding those dogs to each other,… Sue Ann Bowling. It is derived from the "game" pit bull and mastiff breeds intertwined along with the bulldog breeds. This genetic site is responsible for diluted pigment which lightens coats from black or brown to gray or blue or very pale brown.A mutation in the melanophilin (MLPH) gene is the cause of color dilution. While genetics is not set in stone and can be morphed and mutated there is no real precise method of knowing what can be produced.. The Genetics of Breed Color In The American Pit Bull Terrier by Amy Greenwood Burford B.S January 19, 2013 at 12:16 AM One of my responsibilities as a member of the staff of the American Dog Breeders Association is to be the ‘color expert’. However, if you'd like to play with it or offer feedback please pm me and I'll send you the link. Further, the same genes may give a very different effect on different types and lengths of coats. Dog coat color, shape, and length genetics are based in 16 specific locations of the geneome. Typically the color "blue" is largely dominate however if your other dog is not a carrier in order for this to occur in frequent.. Dogs with very light tan probably are cchcch or something similar. Above are expanded descriptions of the genetic tests offered by the Veterinary Genetics Laboratory for dog coat color. Black and silver replacing black and tan, or a wolf-like color without the extra banding (see aw, above) may also be due to a cchcch genotype. I have written a puppy coat color calculator and would like some feedback. I'm not going to post a link as I don't want to violate the terms of this website (might be considered advertising). The basic color loci are: Agouti Locus (A), Brown locus (B), Dilute locus (D), Extention locus (E), Harlequin locus (H), dominant black locus (K), Merle locus (M), and Spotting locus (S). Dogs have a wide variety of genes that influence color. Other genes that add white patterns and dilute colors are also present in dogs but are specific to certain breeds. Brown dogs show lightening even of eumelanin pigment and are thought to be due to a bbcchcch genetic makeup.